LrgpV1, Main, Exploration, bibRecord, 000A23

Quantum Dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer

Identifieur interne : 000A23 ( Main/Exploration ); précédent : 000A22; suivant : 000A24

Quantum Dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer

Auteurs : Vincent Morosini [France] ; Thierry Bastogne [France] ; Céline Frochot [France] ; Raphaël Schneider [France] ; Aurélie François [France] ; François Guillemin [France] ; Muriel Barberi-Heyob [France]

Source :

Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences [ 1474-905X ] ; 2011-05.

RBID : Hal:hal-00580535

Abstract

This study examined the in vitro potential of bioconjugated quantum dots (QDs) as photosensitizers for photodynamic therapy (PDT). According to our previous approaches using photosensitizers, folic acid appears to be an optimal targeting ligand for selective delivery of attached therapeutic agents to cancer tissues. We synthesized hydrophilic near infrared emitting CdTe(S)-type QDs conjugated with folic acid using different spacers. Photodynamic efficiency of QDs conjugated or not with folic acid was evaluated on KB cells, acting as a positive control due to their overexpression of FR-α, and HT-29 cells lacking FR-α, as negative control. A design of experiments was suggested as a rational solution to evaluate the impacts of each experimental factor (QD type and concentration, light fluence and excitation wavelength, time of contact before irradiation and cell phenotype). We demonstrated that, for concentrations lower than 10 nM, QDs displayed practically no cytotoxic effect without light exposure for both cell lines. Whereas QDs at 2.1 nM displayed a weak photodynamic activity, a concentration of 8 nM significantly enhanced the photodynamic efficiency characterized by a light dose-dependent response. A statistically significant difference in photodynamic efficiency between KB and HT-29 cells was evidenced in the case of folic acid-conjugated QDs. Optimal conditions led to an enhanced photocytotoxicity response, allowing us to validate the ability of QDs to generate a photodynamic effect and of folic acid-conjugated QDs for targeted PDT.

Url:

https://hal.archives-ouvertes.fr/hal-00580535

DOI: 10.1039/C0PP00380H

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000958
to stream Hal, to step Curation: 000958
to stream Hal, to step Checkpoint: 000891
to stream Main, to step Merge: 000B25
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Le document en format XML

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<author><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name>
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<author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
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<idno type="DOI">10.1039/C0PP00380H</idno>
<series><title level="j">Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences</title>
<idno type="ISSN">1474-905X</idno>
<imprint><date type="datePub">2011-05</date>
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<front><div type="abstract" xml:lang="en">This study examined the in vitro potential of bioconjugated quantum dots (QDs) as photosensitizers for photodynamic therapy (PDT). According to our previous approaches using photosensitizers, folic acid appears to be an optimal targeting ligand for selective delivery of attached therapeutic agents to cancer tissues. We synthesized hydrophilic near infrared emitting CdTe(S)-type QDs conjugated with folic acid using different spacers. Photodynamic efficiency of QDs conjugated or not with folic acid was evaluated on KB cells, acting as a positive control due to their overexpression of FR-α, and HT-29 cells lacking FR-α, as negative control. A design of experiments was suggested as a rational solution to evaluate the impacts of each experimental factor (QD type and concentration, light fluence and excitation wavelength, time of contact before irradiation and cell phenotype). We demonstrated that, for concentrations lower than 10 nM, QDs displayed practically no cytotoxic effect without light exposure for both cell lines. Whereas QDs at 2.1 nM displayed a weak photodynamic activity, a concentration of 8 nM significantly enhanced the photodynamic efficiency characterized by a light dose-dependent response. A statistically significant difference in photodynamic efficiency between KB and HT-29 cells was evidenced in the case of folic acid-conjugated QDs. Optimal conditions led to an enhanced photocytotoxicity response, allowing us to validate the ability of QDs to generate a photodynamic effect and of folic acid-conjugated QDs for targeted PDT.</div>
</front>
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<tree><country name="France"><region name="Grand Est"><name sortKey="Morosini, Vincent" sort="Morosini, Vincent" uniqKey="Morosini V" first="Vincent" last="Morosini">Vincent Morosini</name>
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<name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name>
<name sortKey="Bastogne, Thierry" sort="Bastogne, Thierry" uniqKey="Bastogne T" first="Thierry" last="Bastogne">Thierry Bastogne</name>
<name sortKey="Francois, Aurelie" sort="Francois, Aurelie" uniqKey="Francois A" first="Aurélie" last="François">Aurélie François</name>
<name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name>
<name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name>
<name sortKey="Schneider, Raphael" sort="Schneider, Raphael" uniqKey="Schneider R" first="Raphaël" last="Schneider">Raphaël Schneider</name>
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Quantum Dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer

Quantum Dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer

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